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A 2-year open label safety examine conducted in youngsters and adolescents (ages 6-17) with ADHD enrolled 314 patients. Amfetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. The prodrug, lisdexamfetamine, doesn’t bind to the sites answerable for the reuptake of norepinephrine and dopamine in vitro. Lisdexamfetamine dimesylate is a pharmacologically inactive prodrug. After oral administration, lisdexamfetamine is rapidly absorbed from the gastrointestinal tract and hydrolysed primarily by red blood cells to dexamfetamine, which is answerable for the drug’s exercise.
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The following table presents all adverse reactions based mostly on clinical trials and spontaneous reporting. Lisdexamfetamine dimesylate shouldn’t be used during breast-feeding. Ascorbic acid and other brokers and conditions (thiazide diuretics, diets high in animal protein, diabetes, respiratory acidosis) that acidify urine enhance urinary excretion and decrease the half-life of amfetamine.
Lisdexamfetamine dimesylate may cause dizziness, drowsiness and visible disturbances including difficulties with accommodation, and blurred vision. These may have a average influence on the flexibility to drive and use machines. Patients should be warned of those attainable results and suggested that if affected, they should avoid probably hazardous actions corresponding to driving or operating equipment.
(b) The particular person in cost shall not be engaged on any duties which can prevent him from exercising general supervision and he shall be assisted as necessary by suitable grownup persons to ensure enough supervision. The particular person in cost ought to be conversant with these
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